Kindlins
نویسندگان
چکیده
What is your favourite/least favourite conference? I was inspired by the Cold Spring Harbour Meetings on Human Evolution and Disease in the 1990s which brought together the scientific world elite from various fields of human evolution. Unfortunately, dedicated conferences that include specialists from different fields working on human evolution such as palaeontology, archaeology, linguistic, biological and cultural anthropology are rare. Although it is not always easy to find a common language between people of such diverse disciplines, it is possible. I know this from my time at the Max Planck Institute for Evolutionary Anthropology in Leipzig, where such an interdisciplinary approach to human evolution is practised with great success.
منابع مشابه
Of Kindlins and Cancer.
Kindlins are 4.1-ezrin-ridixin-moesin (FERM) domain containing proteins. There are three kindlins in mammals, which share high sequence identity. Kindlin-1 is expressed primarily in epithelial cells, kindlin-2 is widely distributed and is particularly abundant in adherent cells, and kindlin-3 is expressed primarily in hematopoietic cells. These distributions are not exclusive; some cells expres...
متن کاملThe Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3
Increased ligand binding to cellular integrins ("activation") plays important roles in processes such as development, cell migration, extracellular matrix assembly, tumor metastasis, hemostasis, and thrombosis. Integrin activation encompasses both increased integrin monomer affinity and increased receptor clustering and depends on integrin-talin interactions. Loss of kindlins results in reduced...
متن کاملKindlins: essential regulators of integrin signalling and cell-matrix adhesion.
Integrin-mediated cell-ECM (extracellular matrix) adhesion is a fundamental process that controls cell behaviour. For correct cell-ECM adhesion, both the ligand-binding affinity and the spatial organization of integrins must be precisely controlled; how integrins are regulated, however, is not completely understood. Kindlins constitute a family of evolutionarily conserved cytoplasmic components...
متن کاملKindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3
Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is sufficient to activate purified integrin αIIbβ3 in vitro. Since talin is localized to the cytoplasm of unstimulated platelets, its re-localization to the pl...
متن کاملPhylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
Kindlin proteins represent a newly discovered family of evolutionarily conserved FERM domain-containing proteins. This family includes three highly conserved proteins: Kindlin-1, Kindlin-2 and Kindlin-3. All three Kindlin proteins are associated with focal adhesions and are involved in integrin activation. The FERM domain of each Kindlin is bipartite and plays a key role in integrin activation....
متن کاملGenetic analyses of Kindlins in mice
Article Chronology: Received 28 March 2006 Revised version received 6 June 2006 Accepted 13 June 2006 Available online 29 June 2006 The three Kindlins are a novel family of focal adhesion proteins. The Kindlin-1 (URP1) gene is mutated in Kindler syndrome, the first skin blistering disease affecting actin attachment in basal keratinocytes. Kindlin-2 (Mig-2), the best studied member of this famil...
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ورودعنوان ژورنال:
- Current Biology
دوره 21 شماره
صفحات -
تاریخ انتشار 2011